2010-09-01 · Atypical fibroxanthoma (AFX) is an uncommon cutaneous neoplasm that usually presents as a rapidly-growing nodule in sun-exposed sites in elderly patients. Despite its highly atypical histological appearance it is almost always associated with innocuous clinical behaviour.

Histologic Findings. The pathologic appearance of atypical fibroxanthoma (AFX) belies the usually excellent prognosis. As shown in the image below, this nonencapsulated dermal tumor is composed of large, fibrocytic, spindle-shaped and anaplastic cells arranged in a haphazard fashion, occasionally in fascicles, and usually with an increased number of mitotic figures.

Once enough cells are produced to replace the old ones, normal cells stop dividing. Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation. Histologically similar to atypical fibroxanthoma but larger and shows substantial involvement of the subcutis or beyond, perineural invasion, lymphovascular invasion or necrosis Behaves in a more aggressive manner than atypical fibroxanthoma Melanoma: Usually associated with an in situ component in the overlying epidermis Abstract Background: Atypical fibroxanthoma (AFX) is an uncommon, rapidly growing cutaneous neoplasm of uncertain histogenesis. Thus far, there are no guidelines for diagnosis and therapy of this tumor. Microscopically, it is characterized by the presence of highly atypical cytologic features, pleomorphism and abundant mitotic figures. The vast majority of patients have an excellent prognosis following conservative therapy.

Leiomyosarcoma : Usually positive for smooth muscle markers, such as smooth muscle myosin and desmin. Metastatic carcinoma : I’m sorry to hear that you’ve been recently diagnosed with Atypical Fibroxanthoma (AFx) in addition to lung cancer. Here is a short video of Mayo Clinic dermatologic surgeon, Dr. Jerry Brewer discussing AFx. He tells us about the risk factors, diagnosis and treatment of this rare form of skin cancer. Atypical fibroxanthoma is a skin cancer often seen in sun-exposed areas. It resembles squamous cell carcinoma or basal cell carcinoma because of the presence of a pink papule or erosion. It is usually diagnosed only after biopsy. Tumors involving the dermis and superficial fat are termed atypical fibroxanthoma and rarely metastasize.

2013-03-26

Se hela listan på librepathology.org Metastatic Atypical Fibroxanthoma: Case Report of an Uncommon Pathology in the Head and Neck Introduction Atypical fibroxanthoma (AFX) is a rare skin malignancy generally developed in elderly male patients with actinic damage. Due to its low rate of metastasis, it is considered a benign neoplasm [1,2]. An atypical fibroxanthoma is a rare, malignant fibrohistiocytic neoplasm, which develops most commonly on the sun-exposed skin of elderly individuals.

2020-09-10

The etiology of atypical fibroxanthomas is poorly understood. The development Atypical fibroxanthomas are surgically removed and have a good prognosis. They might locally reoccur with the Atypical fibroxanthoma also known as AFX is a form of skin cancer that primarily occurs in older adults. Long-term Prognosis Following This Diagnosis. Nov 3, 2017 Atypical fibroxanthoma generally has a good prognosis, and usually complete excision and regular follow-up are recommended. Pleomorphic Atypical Fibroxanthoma of the skin (AFX) is an uncommon tumor of sun-exposed areas of elderly white men, most commonly on the scalp and ears.

They form on the head and neck area, in most cases, and may ulcerate and bleed; Complete excision by surgery is curative and the prognosis of Atypical Fibroxanthoma is usually excellent. However, occasionally the tumors are known to recur BACKGROUND Atypical fibroxanthoma (AFX) is an uncommon superficial fibrohistiocytic tumor. It was originally described as a low‐grade dermal tumor of atypical spindle cells, but this view has changed, and it is generally considered to be a tumor of intermediate malignant potential.
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Atypical fibroxanthoma (AFX) is a nodular dermal ulcerative lesion with a favorable prognosis. AFX most commonly occurs on sun-exposed skin in elderly individuals. Atypical fibroxanthoma (AFX) was first described by Helwig as a low-grade sarcoma with a favorable prognosis . However, since inception, it has been the source of controversy. Despite being markedly pleomorphic, metastases occur in less than 1 percent of cases, with the majority preceded by tumor recurrence [ 1 , 2 , 3 ].

Atypical fibroxanthoma (AFX) is a tumor that occurs primarily in older individuals after the skin of the head and neck has been damaged significantly by sun exposure and/or therapeutic radiation.
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Definition. A morphologic variant of atypical fibroxanthoma characterized by the presence of spindle-shaped fibrohistiocytic cells and a storiform growth pattern. [from NCI]

AFX most commonly occurs on sun-exposed skin in elderly individuals.